Wiley, Angewandte Chemie International Edition, 23(56), p. 6646-6650
Wiley, Angewandte Chemie, 23(129), p. 6746-6750, 2017
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AbstractA new method was developed for the first catalytic enantioselective borylation of aliphatic ketones. A variety of substrates reacted efficiently with bis(pinacolato)diboron in the presence of a copper(I)/chiral N‐heterocyclic carbene complex catalyst to furnish optically active tertiary α‐hydroxyboronates with moderate to high enantioselectivities (up to 94 % ee). Notably, the product could be converted into the chiral tertiary alcohol derivative using a stereospecific boron functionalization process. The theoretical study of the mechanism for the enantioselectivity is also described.