Published in
American Society of Hematology, Blood, 4(131), p. 421-425, 2018
DOI: 10.1182/blood-2017-07-797597
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Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL
Journal article published in 2017 by
Sandrine Degryse 
,
Simon Bornschein,
Charles E. de Bock ,
Emilie Leroy,
Marlies Vanden Bempt ,
Sofie Demeyer,
Kris Jacobs,
Ellen Geerdens,
Olga Gielen,
Jean Soulier,
Christine J. Harrison,
Stefan N. Constantinescu,
Jan Cools
,
Simon Bornschein,
Charles E. de Bock ,
Emilie Leroy,
Marlies Vanden Bempt ,
Sofie Demeyer,
Kris Jacobs,
Ellen Geerdens,
Olga Gielen,
Jean Soulier,
Christine J. Harrison,
Stefan N. Constantinescu,
Jan Cools
This paper is made freely available by the publisher.
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Abstract
Key Points One-third of T-ALL cases with JAK3 mutation harbor 2 JAK3 mutations. Double JAK3 mutants show stronger signaling than single JAK3 mutants.