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Cold Spring Harbor Laboratory Press, Genes & Development, 5(23), p. 549-554, 2009

DOI: 10.1101/gad.1770009

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Pattern formation via small RNA mobility

Journal article published in 2009 by Daniel H. Chitwood ORCID, Fabio T. S. Nogueira, Miya D. Howell, Taiowa A. Montgomery ORCID, James C. Carrington, Marja C. P. Timmermans
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

MicroRNAs and trans-acting siRNAs (ta-siRNAs) have important regulatory roles in development. Unlike other developmentally important regulatory molecules, small RNAs are not known to act as mobile signals during development. Here, we show that low-abundant, conserved ta-siRNAs, termed tasiR-ARFs, move intercellularly from their defined source of biogenesis on the upper (adaxial) side of leaves to the lower (abaxial) side to create a gradient of small RNAs that patterns the abaxial determinant AUXIN RESPONSE FACTOR3. Our observations have important ramifications for the function of small RNAs and suggest they can serve as mobile, instructive signals during development.