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Cold Spring Harbor Laboratory Press, Learning & Memory, 5(12), p. 533-537, 2005

DOI: 10.1101/lm.94505

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Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained

Journal article published in 2005 by Vanesa De la Cruz, Carlos J. Rodriguez-Ortiz ORCID, Ranier Gutiérrez ORCID, Federico Bermudez-Rattoni
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Consolidation theory proposes that through the synthesis of new proteins recently acquired memories are strengthened over time into a stable long-term memory trace. However, evidence has accumulated suggesting that retrieved memory is susceptible to disruption, seeming to consolidate again (reconsolidate) to be retained in long-term storage. Here we show that intracortical blockade of protein synthesis in the gustatory cortex after retrieval of taste-recognition memory disrupts previously consolidated memory to a restricted degree only if the experience is updated. Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory.