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Cold Spring Harbor Laboratory Press, Genes & Development, 19(19), p. 2278-2283, 2005

DOI: 10.1101/gad.1324805

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The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

Journal article published in 2005 by T. Keith Blackwell, Hideki Inoue, Naoki Hisamoto, Jae Hyung An, Riva P. Oliveira ORCID, Eisuke Nishida, T. Keith Blackwell, Kunihiro Matsumoto
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The evolutionarily conserved p38 mitogen-activated protein kinase (MAPK) cascade is an integral part of the response to a variety of environmental stresses. Here we show that the Caenorhabditis elegans PMK-1 p38 MAPK pathway regulates the oxidative stress response via the CNC transcription factor SKN-1. In response to oxidative stress, PMK-1 phosphorylates SKN-1, leading to its accumulation in intestine nuclei, where SKN-1 activates transcription of gcs-1, a phase II detoxification enzyme gene. These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress.