Published in
American Society of Hematology, Blood, 1(132), p. 89-100
DOI: 10.1182/blood-2017-11-814244
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Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis
Journal article published in 2018 by
Ivan K. Chinn 
,
Olive S. Eckstein,
Erin C. Peckham-Gregory,
Baruch R. Goldberg,
Lisa R. Forbes,
Sarah K. Nicholas,
Emily M. Mace,
Tiphanie P. Vogel,
Harshal A. Abhyankar,
Maria I. Diaz,
Helen E. Heslop,
Robert A. Krance,
Caridad A. Martinez,
Trung C. Nguyen,
Dalia A. Bashir
and other authors.
,
Olive S. Eckstein,
Erin C. Peckham-Gregory,
Baruch R. Goldberg,
Lisa R. Forbes,
Sarah K. Nicholas,
Emily M. Mace,
Tiphanie P. Vogel,
Harshal A. Abhyankar,
Maria I. Diaz,
Helen E. Heslop,
Robert A. Krance,
Caridad A. Martinez,
Trung C. Nguyen,
Dalia A. Bashir
and other authors.
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Abstract
Key Points Whole-exome sequencing may identify specific therapeutic opportunities for patients with HLH. HLH should be conceptualized as a critical illness phenotype driven by toxic activation of immune cells from different underlying mechanisms.