AbstractThis paper presents a novel multiple measurement information fusion approach to the estimation of cardiovascular risk predictors from non-invasive pulse volume waveforms measured at the body’s diametric (arm and ankle) locations. Leveraging the fact that diametric pulse volume waveforms originate from the common central pulse waveform, the approach estimates cardiovascular risk predictors in three steps by: (1) deriving lumped-parameter models of the central-diametric arterial lines from diametric pulse volume waveforms, (2) estimating central blood pressure waveform by analyzing the diametric pulse volume waveforms using the derived arterial line models, and (3) estimating cardiovascular risk predictors (including central systolic and pulse pressures, pulse pressure amplification, and pulse transit time) from the arterial line models and central blood pressure waveform in conjunction with the diametric pulse volume waveforms. Experimental results obtained from 164 human subjects with a wide blood pressure range (systolic 144 mmHg and diastolic 103 mmHg) showed that the approach could estimate cardiovascular risk predictors accurately (r ≥ 0.78). Further analysis showed that the approach outperformed a generalized transfer function regardless of the degree of pulse pressure amplification. The approach may be integrated with already available medical devices to enable convenient out-of-clinic cardiovascular risk prediction.