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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(49), p. 2554-2557, 2005

DOI: 10.1128/aac.49.6.2554-2557.2005

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Levofloxacin Disposition over Time in Aqueous Humor of Patients Undergoing Cataract Surgery

Journal article published in 2005 by Federico Pea ORCID, Ettore Ferrari, Federica Pavan, Derri Roman-Pognuz, Francesco Bandello, Mario Furlanut
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.