American Association for the Advancement of Science, Science, 6411(362), 2018
Association for Research in Vision and Ophthalmology, Journal of Vision, 15(19), p. 15, 2019
DOI: 10.1167/19.15.15
Yearbook of Paediatric Endocrinology, 2019
DOI: 10.1530/ey.16.3.2
Full text: Download
Thyroid hormone in color vision development Cone photoreceptors in the eye enable color vision, responding to different wavelengths of light according to what opsin pigments they express. Eldred et al. studied organoids that recapitulate the development of the human retina and found that differentiation of cone cells into their tuned subtypes was regulated by thyroid hormone. Cones expressing short-wavelength (S) opsin developed first, and cones expressing long- and medium-wavelength (L/M) opsin developed later. The switch toward development of L/M cones depended on thyroid hormone signaling through the nuclear thyroid hormone receptor. Science , this issue p. eaau6348