Published in

American Society of Hematology, Blood, 8(130), p. 995-1006

DOI: 10.1182/blood-2016-10-747303

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Tonic B-cell receptor signaling in diffuse large B-cell lymphoma

Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Data provided by SHERPA/RoMEO

Abstract

Key Points The GCB subtype of DLBCL relies exclusively on tonic BCR signaling via CD79A Y188. PTEN protein expression and BCR surface density determine the contribution of tonic BCR signaling to AKT activity in GCB-DLBCL.