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American Society of Hematology, Blood, p. blood-2018-01-829663

DOI: 10.1182/blood-2018-01-829663

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Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Journal article published in 2018 by Simranpreet Kaur ORCID, Liza J. Raggatt, Susan M. Millard ORCID, Andy C. Wu, Lena Batoon, Rebecca N. Jacobsen, Ingrid G. Winkler ORCID, Kelli P. MacDonald ORCID, Andrew C. Perkins, David A. Hume, Jean-Pierre Levesque ORCID, Allison R. Pettit ORCID
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Abstract

Key Points Recipient macrophages persist in hematopoietic tissues and self-repopulate via in situ proliferation after syngeneic transplantation. Targeted depletion of recipient CD169+ macrophages after transplant impaired long-term bone marrow engraftment of hematopoietic stem cells.