Published in
American Society of Hematology, Blood, 21(131), p. 2335-2344
DOI: 10.1182/blood-2018-02-835561
immuneACCESS, 2018
DOI: 10.21417/b7xs7j
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Patients with CD3G mutations reveal a role for human CD3g in Treg diversity and suppressive function
Journal article published in 2018 by
Jh Rowe,
Om Delmonte,
Sevgi Keles 
,
Bd Stadinski ,
Ak Dobbs ,
Lauren A. Henderson ,
Yasuhiro Yamazaki ,
Lm Allende ,
Fa Bonilla ,
Li Gonzalez-Granado ,
Christina Yee ,
Seyma Celikbilek Celik,
Sn Guner ,
Hasan Kapakli,
C. Lee
and other authors.
,
Bd Stadinski ,
Ak Dobbs ,
Lauren A. Henderson ,
Yasuhiro Yamazaki ,
Lm Allende ,
Fa Bonilla ,
Li Gonzalez-Granado ,
Christina Yee ,
Seyma Celikbilek Celik,
Sn Guner ,
Hasan Kapakli,
C. Lee
and other authors.
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Abstract
Key Points CD3γ-deficient patients manifest T-cell phenotypic and functional defects that are especially prominent in Treg cells. The peripheral T-cell repertoire of CD3γ-deficient patients is restricted, with molecular signatures of self-reactivity.