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Oxford University Press (OUP), Bioinformatics, 12(26), p. i294-i300

DOI: 10.1093/bioinformatics/btq192

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Low-homology protein threading

Journal article published in 2010 by Jian Peng ORCID, Jinbo Xu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: The challenge of template-based modeling lies in the recognition of correct templates and generation of accurate sequence-template alignments. Homologous information has proved to be very powerful in detecting remote homologs, as demonstrated by the state-of-the-art profile-based method HHpred. However, HHpred does not fare well when proteins under consideration are low-homology. A protein is low-homology if we cannot obtain sufficient amount of homologous information for it from existing protein sequence databases.