Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(63), 2019
DOI: 10.1128/aac.01310-18
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Drug Interactions Between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine
,
Mohammed Lamorde,
Catriona Waitt,
Julian Kaboggoza,
Laura Else,
Pauline Byakika-Kibwika,
Alieu Amara,
Joshua Gini,
Markus Winterberg,
Justin Chiong,
Joel Tarning ,
Saye H. Khoo
Full text: Unavailable
Abstract
Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether-lumefantrine or artesunate-amodiaquine given with 50 mg once daily dolutegravir (DTG) to investigate the drug-drug interaction between artemether-lumefantrine or artesunate-amodiaquine and dolutegravir.