Published in
American Society of Hematology, Blood, 5(128), p. 667-679, 2016
DOI: 10.1182/blood-2016-01-690743
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Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Journal article published in 2016 by
Marina Bolzoni 
,
Martina Chiu ,
Fabrizio Accardi,
Rosanna Vescovini,
Massimiliano G. Bianchi ,
Irma Airoldi,
V. DallAsta,
Paola Storti ,
Bianchi Mg,
Katia Todoerti,
Manfredi Allegri,
Amelia Barilli,
Luca Agnelli,
Francesco Nicolini,
Valeria Dall’Asta
and other authors.
,
Martina Chiu ,
Fabrizio Accardi,
Rosanna Vescovini,
Massimiliano G. Bianchi ,
Irma Airoldi,
V. DallAsta,
Paola Storti ,
Bianchi Mg,
Katia Todoerti,
Manfredi Allegri,
Amelia Barilli,
Luca Agnelli,
Francesco Nicolini,
Valeria Dall’Asta
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Myeloma cells produce ammonium in the presence of glutamine, showing high glutaminase and low glutamine synthetase expression. Myeloma cells show high expression of glutamine transporters and inhibition of ASCT2 transporter hinders myeloma growth.