Published in
American Society of Hematology, Blood, 15(130), p. 1746-1756, 2017
DOI: 10.1182/blood-2017-02-770768
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Twinfilin 2a regulates platelet reactivity and turnover in mice
Journal article published in 2017 by
Simon Stritt 
,
Sarah Beck,
Isabelle C. Becker,
Timo Vögtle ,
Markku Hakala ,
Katrin G. Heinze,
Xiaoping Du,
Markus Bender,
Attila Braun,
Pekka Lappalainen,
Bernhard Nieswandt
,
Sarah Beck,
Isabelle C. Becker,
Timo Vögtle ,
Markku Hakala ,
Katrin G. Heinze,
Xiaoping Du,
Markus Bender,
Attila Braun,
Pekka Lappalainen,
Bernhard Nieswandt
This paper is made freely available by the publisher.
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Abstract
Key PointsDeficiency in twinfilin 2a causes macrothrombocytopenia and hyperreactivity of platelets in mice. We provide the first in vivo evidence for an inhibitory function of twinfilin 2a in platelet actin dynamics.