Published in

American Society of Hematology, Blood, 6(128), p. 794-804

DOI: 10.1182/blood-2015-11-680876

Links

Tools

Export citation

Search in Google Scholar

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Journal article published in 2016 by Lucie Leveque-El mouttie ORCID, Motoko Koyama, Laetitia Le Texier, Kate A. Markey ORCID, Melody Cheong, Rachel D. Kuns, Katie E. Lineburg ORCID, Bianca E. Teal, Kylie A. Alexander, Andrew D. Clouston ORCID, Bruce R. Blazar ORCID, Geoffrey R. Hill ORCID, Kelli P. A. MacDonald ORCID
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

Full text: Unavailable

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Key Points Acute GVHD leads to defective MHC class II antigen presentation by donor DC, leading to a failure of peripheral Treg homeostasis. Impaired Treg homeostasis results in chronic GVHD directly and can be alleviated by adoptive Treg transfer.