Dissemin is shutting down on January 1st, 2025

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American Society of Neuroradiology, American Journal of Neuroradiology, 9(29), p. 1644-1648

DOI: 10.3174/ajnr.a1131

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Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved (1)H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.