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Wiley, Chemistry - A European Journal, 43(17), p. 11991-11993, 2011

DOI: 10.1002/chem.201100467

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Iron-Catalyzed Coupling of Aryl Grignard Reagents with Alkyl Halides: A Competitive Hammett Study**

Journal article published in 2011 by Anna Hedström, Ulla Bollmann ORCID, Jenny Bravidor, Per-Ola Norrby
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Competing for electrophiles: The elusive iron-catalyzed CC coupling reaction was investigated and analyzed by a Hammett study of the nucleophilic partner. This required finding conditions in which the iron catalyst is stable in the presence of an excess of the Grignard reagent. The selectivity-determining step seems to be the transmetalation, occurring either before or after the oxidative addition step (see scheme).