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MDPI, Marine Drugs, 11(9), p. 2220-2235, 2011

DOI: 10.3390/md9112220

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New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

Journal article published in 2011 by Francisco Cen Pacheco, Janny A. Villa-Pulgarin, Faustino Mollinedo, Manuel Norte Martín, José Javier Fernández, Antonio Hernández Daranas ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.