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American Society for Microbiology, Applied and Environmental Microbiology, 4(72), p. 2672-2678, 2006

DOI: 10.1128/aem.72.4.2672-2678.2006

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Both msa Genes in Renibacterium salmoninarum Are Needed for Full Virulence in Bacterial Kidney Disease

Journal article published in 2006 by Alison M. Coady ORCID, Anthony L. Murray, Diane G. Elliott, Linda D. Rhodes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Renibacterium salmoninarum , a gram-positive diplococcobacillus that causes bacterial kidney disease among salmon and trout, has two chromosomal loci encoding the major soluble antigen ( msa ) gene. Because the MSA protein is widely suspected to be an important virulence factor, we used insertion-duplication mutagenesis to generate disruptions of either the msa1 or msa2 gene. Surprisingly, expression of MSA protein in broth cultures appeared unaffected. However, the virulence of either mutant in juvenile chinook salmon ( Oncorhynchus tshawytscha ) by intraperitoneal challenge was severely attenuated, suggesting that disruption of the msa1 or msa2 gene affected in vivo expression.