Published in
American Society of Hematology, Blood, p. blood-2018-04-845602
DOI: 10.1182/blood-2018-04-845602
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Srsf2 P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Journal article published in 2018 by
Monique F. Smeets,
Shuh Ying Tan,
Jane Jialu Xu,
Govardhan Anande,
Ashwin Unnikrishnan,
Alistair M. Chalk 
,
Scott R. Taylor,
John E. Pimanda,
Meaghan Wall,
Louise E. Purton,
Carl R. Walkley
,
Scott R. Taylor,
John E. Pimanda,
Meaghan Wall,
Louise E. Purton,
Carl R. Walkley
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Abstract
Key Points Srsf2 P95H/+ mutation within hemopoietic stem cells is required to initiate myeloid-biased hemopoiesis. Mutation of Srsf2 is sufficient to initiate the development of MDS/MPN in vivo in the setting of native hemopoiesis.