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Oxford University Press (OUP), Integrative & Comparative Biology, 4(47), p. 552-577

DOI: 10.1093/icb/icm072

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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia.

Journal article published in 2007 by David Hoogewijs, Nb B. Terwilliger, Ka A. Webster, Ja A. Powell-Coffman, S. Tokishita, H. Yamagata, T. Hankeln, T. Burmester ORCID, Kt T. Rytkönen, M. Nikinmaa ORCID, D. Abele, K. Heise, M. Lucassen, J. Fandrey, Ph H. Maxwell and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.