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American Association for the Advancement of Science, Science, 6312(354), 2016

DOI: 10.1126/science.aag0839

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Exploring genetic suppression interactions on a global scale

Journal article published in 2016 by Jolanda van Leeuwen ORCID, Carles Pons ORCID, M. M. U aj, Joseph C. Mellor, Takafumi N. Yamaguchi, Mellor Jc, Helena Friesen, John Koschwanez, Mojca Mattiazzi Ušaj, M. U aj, Maria Pechlaner, Yamaguchi Tn, Benjamin VanderSluis, Mehmet Takar, Kerry Andrusiak and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set reveals a set of general properties that can be used to predict suppression interactions. Furthermore, the study provides a template for extending suppression studies to other genes or to more complex organisms. Science , this issue p. 599