Published in
American Association for the Advancement of Science, Science, 6312(354), 2016
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Exploring genetic suppression interactions on a global scale
,
Carles Pons ,
M. M. U aj,
Joseph C. Mellor,
Takafumi N. Yamaguchi,
Mellor Jc,
Helena Friesen,
John Koschwanez,
Mojca Mattiazzi Ušaj,
M. U aj,
Maria Pechlaner,
Yamaguchi Tn,
Benjamin VanderSluis,
Mehmet Takar,
Kerry Andrusiak
and other authors.
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Abstract
A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set reveals a set of general properties that can be used to predict suppression interactions. Furthermore, the study provides a template for extending suppression studies to other genes or to more complex organisms. Science , this issue p. 599