The purpose of the present study was to evaluate the changes in movement velocity during resistance training with different loads while the trainees attempted to move the load at a predetermined repetition duration. Twenty-one resistance-trained men (age: 25.7 ± 5 years; height: 177.0 ± 7.2 cm; mass: 85.4 ± 13.56 kg) volunteered to participate in the study. Participants performed 2 test sessions. The first to determine 1-repetition maximum (1RM) load, and the second to evaluate velocity loss during a set to failure performed at 75% and 50% of 1RM using a 2-s concentric and 2-s eccentric repetition duration, controlled by a mobile app metronome. When using 75% 1RM there was a significant loss of movement velocity between the antepenultimate and the penultimate repetition (5.33%, p < 0.05), as well as during the penultimate and the last (22.11%, p < 0.05). At 50% of 1RM the participants performed the set until momentary failure without significant velocity loss. Monitoring velocity loss during high-load resistance training through simple methods can be an important tool for standardize the intensity of effort employed during submaximal training. This can be useful in clinical conditions where maximum exertions are contraindicated or when specific logistics are lacking.