Published in

Future Medicine, Personalized Medicine, 4(13), p. 325-336, 2016

DOI: 10.2217/pme-2016-0030

Links

Tools

Export citation

Search in Google Scholar

Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes

Journal article published in 2016 by Ramu Adela, Soheb Anwar Mohammed, Abhinav Kanwal, Gayatri Vishwakarma, Podduturi Naveen Chander Reddy, Sanjay K. Banerjee ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Aim: Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM_HTN; n = 36). Results: T2DM and T2DM_HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM_HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Conclusion: Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.