Abstract An interannual variability mode in the southeast Pacific with a physical interpretation similar to that of the Pacific meridional mode (PMM) in the North Pacific was recently identified. Both modes have been shown to influence the subsequent development of El Niño–Southern Oscillation (ENSO) events. This study investigates the relationship between ENSO and the two PMMs using observational and reanalysis data. The results show that the South Pacific meridional mode (SPMM) mainly favors the development of sea surface temperature anomalies (SSTAs) in the eastern equatorial Pacific, whereas the North Pacific meridional mode (NPMM) mainly favors the development of SSTAs in the central equatorial Pacific. Both of the meridional modes are considered to be analogous in terms of their physical interpretation and can be important predictors of ENSO when considering different flavors of ENSO. Neither the NPMM nor the SPMM can be precluded as accurate indicators when forecasting particular flavors of ENSO.