Published in
Royal Society of Chemistry, Chemical Science, 5(8), p. 3871-3878, 2017
DOI: 10.1039/c6sc05313k
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- Royal Society of Chemistry
- [www.ncbi.nlm.nih.gov] | PDF
- [www.research.ed.ac.uk] | PDF
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- [europepmc.org] | PDF
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Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst
Journal article published in 2017 by
Terence T.-L. Kwan,
Omar Boutureira 
,
Elizabeth C. Frye,
Stephen J. Walsh ,
Moni K. Gupta,
Stephen Wallace,
Yuteng Wu,
Fengzhi Zhang,
Hannah F. Sore,
Warren R. J. D. Galloway,
Jason W. Chin,
Martin Welch,
Gonçalo J. L. Bernardes ,
David R. Spring
,
Elizabeth C. Frye,
Stephen J. Walsh ,
Moni K. Gupta,
Stephen Wallace,
Yuteng Wu,
Fengzhi Zhang,
Hannah F. Sore,
Warren R. J. D. Galloway,
Jason W. Chin,
Martin Welch,
Gonçalo J. L. Bernardes ,
David R. Spring
This paper is made freely available by the publisher.
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Abstract
The development of site-specific modification of alkyne-functionalized proteins using dimethylarylsilanes and substoichiometric or low-loading of Ru(ii) catalysts is reported. Furthermore, the resultant gem-vinylsilane can undergo further targeted chemical modifications, highlighting its potential for single-site, dual-modification applications.