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Dove Press, Nature and Science of Sleep, p. 43

DOI: 10.2147/nss.s75166

Elsevier, Sleep Medicine, (16), p. S25, 2015

DOI: 10.1016/j.sleep.2015.02.061

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All-cause mortality from obstructive sleep apnea in male and female patients with and without continuous positive airway pressure treatment: a registry study with 10 years of follow-up

Journal article published in 2015 by Poul Jennum, Jennum,Poul, Philip Tønnesen, Tønnesen,Philip, Rikke Ibsen, Ibsen,Rikke, Jakob Kjellberg ORCID, Kjellberg,Jakob
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Poul Jennum,1,2 Philip Tønnesen,1 Rikke Ibsen,3 Jakob Kjellberg4 1Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup Hospital, Copenhagen, Denmark; 2Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; 3itracks, Aarhus, Denmark, 4Danish National Institute for Local and Regional Government Research, Copenhagen, Denmark Background: More information is needed about the effect on mortality of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA), especially in women. Methods: We employed a historical cohort study design, using data from 25,389 patients with a diagnosis of OSA selected from the Danish National Patient Registry for the period 1999–2009. We used Cox proportional hazard function to evaluate the all-cause mortality from OSA in middle-aged and elderly males and females who were treated, or not, with CPAP. Results: Female OSA patients had a lower mortality than males, irrespective of whether they received CPAP treatment. CPAP treatment improved survival, as illustrated by the hazard ratio of 0.62 (P