Published in
American Society of Hematology, Blood, 10(131), p. 1122-1144, 2018
DOI: 10.1182/blood-2017-02-768077
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Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148
Journal article published in 2018 by
Jun Mori 
,
Zoltan Nagy ,
Giada Di Nunzio,
Christopher W. Smith,
Mitchell J. Geer ,
Rashid Al Ghaithi,
Johanna P. van Geffen,
Silke Heising,
Luke Boothman ,
Bibian M. E. Tullemans,
Joao N. Correia ,
Louise Tee,
Marijke J. E. Kuijpers ,
Paul Harrison ,
Johan W. M. Heemskerk
and other authors.
,
Zoltan Nagy ,
Giada Di Nunzio,
Christopher W. Smith,
Mitchell J. Geer ,
Rashid Al Ghaithi,
Johanna P. van Geffen,
Silke Heising,
Luke Boothman ,
Bibian M. E. Tullemans,
Joao N. Correia ,
Louise Tee,
Marijke J. E. Kuijpers ,
Paul Harrison ,
Johan W. M. Heemskerk
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsCsk and CD148 are nonredundant regulators of SFKs in platelets, and deletion of either induces cell-intrinsic negative feedback mechanisms. Csk is a negative regulator of SFK activity, whereas CD148 is a dual positive and negative regulator of SFK activity in platelets.