American Society of Hematology, Blood, 10(131), p. 1122-1144, 2018
DOI: 10.1182/blood-2017-02-768077
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Key PointsCsk and CD148 are nonredundant regulators of SFKs in platelets, and deletion of either induces cell-intrinsic negative feedback mechanisms. Csk is a negative regulator of SFK activity, whereas CD148 is a dual positive and negative regulator of SFK activity in platelets.