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American Society of Hematology, Blood, 4(130), p. 542-553, 2017

DOI: 10.1182/blood-2016-11-754416

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Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2

This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Key PointsVWF synthesis in liver endothelial cells is regulated by gut microbiota through TLR2 signaling. Reduced plasma VWF levels in GF and Tlr2−/− mice cause reduced thrombus formation at the ligation-injured carotid artery.