Published in
Oxford University Press (OUP), The Journal of Infectious Diseases, 5(203), p. 736-743
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The Y238X Stop Codon Polymorphism in the Human β-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis
Journal article published in 2011 by
Louis Y. A. Chai,
Mark G. J. de Boer 
,
Walter J. F. M. van der Velden,
Theo S. Plantinga,
Annemiek B. van Spriel,
Cor Jacobs,
Constantijn J. M. Halkes,
Alieke G. Vonk,
Nicole M. Blijlevens,
Jaap T. van Dissel,
Peter J. Donnelly,
Bart-Jan Kullberg,
Johan Maertens,
Mihai G. Netea
,
Walter J. F. M. van der Velden,
Theo S. Plantinga,
Annemiek B. van Spriel,
Cor Jacobs,
Constantijn J. M. Halkes,
Alieke G. Vonk,
Nicole M. Blijlevens,
Jaap T. van Dissel,
Peter J. Donnelly,
Bart-Jan Kullberg,
Johan Maertens,
Mihai G. Netea
This paper is made freely available by the publisher.
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Abstract
Background. Dectin-1 is the major receptor for fungal β-glucans on myeloid cells. We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients.