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American Society of Hematology, Blood Advances, 10(2), p. 1146-1156, 2018

DOI: 10.1182/bloodadvances.2018015669

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TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation

Journal article published in 2018 by Wing-Hang Tong ORCID, Nunziata Maio, De-Liang Zhang ORCID, Erika M. Palmieri, Hayden Ollivierre, Manik C. Ghosh, Daniel W. McVicar ORCID, Tracey A. Rouault ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points TLR activation suppresses expression of Fe-S cluster biogenesis factors NFS1, ISCU, HSC20, FXN, ISD11, GLRX5, CIAO1, FAM96A, and FAM96B. Restriction of Fe-S cluster biogenesis not only impairs oxidative metabolism but also modulates histone and tubulin acetylation profiles.