The creep response of the single-crystal nickel-base superalloy MD2 has been investigated in this study. A set of constant load creep experiments was performed loaded in the nominal [001], [011] and [111] crystal orientations. A crystal plasticity - creep relaxation model, based on thermomechanical fatigue stress relaxation tests, was benchmarked to simulate the creep behaviour. The responses from the model were then compared to the results obtained during the creep tests. From the comparison it could observed that a trend for the [001] crystal orientation is present. A relative creep response between the simulations and experiments could be observed for the different stress levels. At high and increasing stress levels the relative relation is increasing. Under a certain stress level the relative relation is instead increasing for decreasing stress levels. This relative relation arises from the stress relaxation evaluation process, in which the creep parameters are defined, presumably due to the high stress relaxation that is present in the initial time frame. No trend was seen for the [011] and [111] crystal orientations. A discrepancy between the simulations and experiments was still obtained, also related to the high stress relaxation of the initial time frame.