National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, 11-12(121), p. 1334-1343, 2013
DOI: 10.1289/ehp.1307297
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Background: The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of xenobiotic detoxification genes and is a critical mediator of gene–environment interactions. Many AHR target genes identified by genome-wide gene expression profiling have morphogenetic functions, suggesting that AHR may play a role in embryonic development.