Published in
American Society of Hematology, Blood, 18(129), p. 2479-2492, 2017
DOI: 10.1182/blood-2016-06-725093
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- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Journal article published in 2017 by
Wei Shi,
Therese Vu,
Didier Boucher,
Anna Biernacka,
Jules Nde,
Raj K. Pandita,
Jasmin Straube,
Glen M. Boyle 
,
Fares Al-Ejeh,
Purba Nag ,
Jessie Jeffery,
Janelle L. Harris,
Amanda L. Bain,
Marta Grzelak,
Magdalena Skrzypczak
and other authors.
,
Fares Al-Ejeh,
Purba Nag ,
Jessie Jeffery,
Janelle L. Harris,
Amanda L. Bain,
Marta Grzelak,
Magdalena Skrzypczak
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Combined loss of Ssb1/Ssb2 induces rapid lethality due to replication stress–associated loss of hematopoietic stem and progenitor cells. Functionally, loss of Ssb1/Ssb2 activates p53 and IFN pathways, causing enforced cell cycling in quiescent HSPCs and apoptotic cell loss.