The goal of this study is to determine whether peripheral blood volume fluctuations triggered by ventricular premature beats (VPBs) are significantly related to hypotensive symptoms during dialysis treatment. Patients treated with hemodialysis often suffer from cardiovascular disorders and uremic neuropathy, increasing the propensity to homeostatic imbalance that, in turn, may result in intradialytic hypotension, cramps, nausea, dizziness, headache and other complications. VPBs, being abundant in hemodialysis patients, can be viewed as an internal disturbance leading to imbalance through acute blood pressure drop and prolonged tissue deoxygenation. The present study investigates and quantifies VPB-induced relative peripheral blood volume changes, measured from the fingertip photoplethysmographic (PPG) waveform, and their significance for characterization of physiological recovery of a disturbed circulatory state. The mean decrease in PPG amplitude, corresponding to an initial post-ectopic drop in blood volume delivered to the periphery, was 4 ± 3% in asymptomatic treatments, whereas 17 ± 3% in symptomatic dialysis treatments. This result indicates that significant differences exist between the two groups of treatment, providing a potential for development of intradialytic risk predictors.