Cross-sectional studies indicate that diversion and injection of buprenorphine intended for oral use is an emerging health issue for Victorian injecting drug users (IDUs). Between June and September 2006 we conducted in-depth interviews with 23 IDUs from Melbourne, Australia, exploring their motivations for engaging in this behavior. Thematic analysis of the data suggests that convenience was a key motivation for buprenorphine injection in Melbourne as buprenorphine is cheap and readily available. “Needle fixation” was also a commonly cited motivation. Participants highlighted a variety of benefits associated with buprenorphine injecting, including reductions in illicit drug use and time spent engaging in drug-seeking behaviors, leading to greater stability in their lives. Interviewees were not well-informed about the risks of injecting drugs designed for sublingual use and vein damage was widespread and occasionally severe. The views expressed by study participants indicate a need to explore more appropriate opiate treatment solutions, including the option of injectable opiate pharmacotherapies.