Published in
American Society of Hematology, Blood, 7(129), p. 883-895, 2017
DOI: 10.1182/blood-2016-06-724245
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A novel mechanism regulating human platelet activation by MMP-2–mediated PAR1 biased signaling
Journal article published in 2016 by
Manuela Sebastiano,
Stefania Momi,
Emanuela Falcinelli,
Loredana Bury,
Marc F. Hoylaerts 
,
Paolo Gresele
,
Paolo Gresele
This paper is made freely available by the publisher.
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Abstract
Key PointsActive MMP-2 enhances platelet activation by cleaving PAR1 at an extracellular site different from the thrombin cleavage site. The novel PAR1-tethered ligand exposed by MMP-2 selectively stimulates PAR1-dependent Gq and G12/13 pathway activation.