Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

van Asperen (Christi), C. J.; harrington (Patricia), P.; Wang (Xing), X.; Zs, Fredericksen; van den Ouweland, Ans Mw W.; Wappenschmidt, Barbara; Wapenschmidt (Barbara), B.; kConFab, The; Walker (Lisa), L. J.; Fredericksen (Zachary), Z.; Lc, Walker; Walker, Logan C.; Tarrell (Robert), R.; Pankratz (Shane), V. S.; Lindor (Noralane), N. M.; Beesley (Jonathan), J.; Healey (Sue), S.; (kConFab), Kathleen Cuningham Foundation Consortium for Research; Chen (Xiaoqing), X.; Fredericksen, Zachary S.; Tirapo (Carole), C.; Giraud (Sophie), S.; Fab, K. Con; Mazoyer (Sylvie), S.; Mazoyer, Sylvie; Muller (Danièle), D. W.; Frickeer, Jean-Pierre; Muller, Danièle; Fricker (Jean Pierre), J. P.; Fricker, Jean-Pierre; Gemo Study Collaborators, The; Wang, Xianshu; Delnatte (Capucine), C. D.; Delnatte, Capucine-D.; Schmutzler, Rita K.; Schmutzler (Rita), R. K.; Gemo, Study Collaborators; (gemo), Groupe Genetique et Cancer; Quad, Mod S.; Engel, Christoph; Schönbuchner, Ines; Engel (Christoph), C.; Tarrell, Robert; Pankratz, Vernon Shane; Deissler, Helmut; Schönbuchner (Ines), I.; Meindl, Alfons; Deissler (Helmut), H.; Hogervorst, Frans B.; A. Meindl, A. (Alfons); Verheus, Martijn; Hogervorst (Frans), F. B. L.; Verheus (Martijn), M.; Lindor, Noralane M.; Hooning, Maartje J.; Vs, Pankratz; Den Ouweland, Ans M. W.; Van Den Ouweland, Ans; Hooning (Maartje), M. J.; Nelen, Marcel R.; Ausems, Margreet Gem E. M.; Nelen (Marcel), M. R.; Ausems (Margreet), M. G. E. M.; Aalfs, Cora M.; Van Asperen, Christi J.; Aalfs (Cora), C.; Nm, Lindor; Devilee (Peter), P.; Tirapo, Carole; Devilee, Peter; Gerrits (Monique), M. M.; Gerrits, Monique M.; (hebon), Hereditary Breast and Ovarian Cancer Research Group Netherlands; Waisfisz, Quinten F.; Beesley, Jonathan; Hebon, The; Giraud, Sophie; Waisfisz (Quinten), Q.; Szabo, Csilla I.; Szabo (Csilla), C.; Easton, Douglas F.; ModSQuaD, The; Easton (Douglas), D. F.; Peock, Susan; ModSQuaD2,; Cook, Margaret; Oliver, Clare T.; Healey, Sue; Peock (Susan), S.; Cook (Jackie), J.; Frost, Debra; Oliver (Clare), C.; Harrington, Patricia; Gareth Evans, D.; Evans, D. Gareth; Frost (Debra), D.; Lalloo, Fiona; Evans (Gareth), D. G.; Eeles, Ros; Lalloo (Fiona), F.; Chen, Xiaoqing; Eeles (Rosalind), R.; Izatt, Louise; Izatt (Louise), L.; Chu, Carol; Chu (Chengbin), C.; Davidson, Rosemarie; Davidson (Rosemarie), R.; Eccles, Diana; Eccles (Diana), D.; Ong, Kai-Ren; Ong (Kai), K. R.; Cook, Jackie; Embrace, The; Cook (Margaret), M.; Stoppa-Lyonnet, Dominique; Rebbeck, Tim; Rebbeck (Timothy), R.; Nathanson, Katherine L.; Nathanson (Katherine), K. L.; Domchek, Susan M.; Domchek (Susan), S. M.; Singer, Christian F.; Singer (Christian), C. F.; Gschwantler-Kaulich, Daphne; Asperen, Christi J.; Dressler, Anne-Catharina; Dressler (Catherina), C.; Pfeiler, Georg; Pfeiler (Georg), G.; Godwin, Andrew K.; Godwin (Andrew), A. K.; Heikinen (Tuomas), T.; Heikkinen, Tuomas; Nevanlinna, Heli; Nevanlinna (Heli), H.; Agnarsson, Bjarni A.; Agnarsson (Bjarni Agnar), B. A.; Caligo, Maria Adelaide; Caligo (Maria), M. A.; Olsson (Hans), H.; Olsson, Håkan; Kristoffersson (Ulf), U.; Kristoffersson, Ulf; Liljegren (Annelie), A.; Liljegren, Annelie; Arver (Brita Wasteson), B.; Arver, Brita; Karlsson (Per), P.; Karlsson, Per; (swe-Brca), Swedish Breast Cancer Study; Melin (Beatrice), B.; Melin, Beatrice; Swe-Brca47,; Sinilnikova, Olga M.; Sinilnikova (Olga), O.; McGuffog, Lesley; McGuffog (Lesley), L.; Antoniou (Antonis), A. C.; Antoniou, Antonis C.; Spurdle (Amanda), A. B.; Chenevix-Trench, Georgia; Schoenbuchner, Ines; Spurdle, Amanda B.; Couch (Fergus), F. J.; Couch, Fergus J.; Fj, Couch; Walker Lc, Fredericksen ZS Wang X Tarrell R Pankratz VS Lindor NM Beesley J Healey S Chen X Kconfab T Stoppa-Lyonnet D Tirapo C Giraud S Mazoyer S Muller D Fricker JP Delnatte C Gemo Study Collaborators T Schmutzler RK Wappenschmidt B Engel C Schonbuchner I Deissler

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BioMed Central, Breast Cancer Research, 6(12), p. R102

DOI: 10.1186/bcr2785

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Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

Journal article published in 2010 by C. J. van Asperen (Christi), P. harrington (Patricia), X. Wang (Xing), Fredericksen Zs, Ans Mw W. van den Ouweland, Barbara Wappenschmidt, B. Wapenschmidt (Barbara), The kConFab, L. J. Walker (Lisa), Z. Fredericksen (Zachary), Walker Lc, Logan C. Walker, R. Tarrell (Robert), V. S. Pankratz (Shane), N. M. Lindor (Noralane) and other authors.

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RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are. ; Abstract Introduction Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies. Methods We successfully genotyped 24 SNPs in a cohort of up to 4,724 BRCA1 and 2,693 BRCA2 female mutation carriers from 15 study groups and assessed whether these variants were associated with risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Results SNPs in five of the 14 candidate genes showed evidence of association with breast cancer risk for BRCA1 or BRCA2 carriers (P

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Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

Abstract