Published in
Wiley, Angewandte Chemie International Edition, 51(51), p. 12721-12726, 2012
Wiley, Angewandte Chemie, 51(124), p. 12893-12898, 2012
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors
Journal article published in 2012 by
Li Tang 
,
Xujuan Yang,
Lawrence W. Dobrucki ,
Isthier Chaudhury,
Qian Yin,
Catherine Yao,
Stéphane Lezmi,
William G. Helferich,
Timothy M. Fan,
Jianjun Cheng
,
Xujuan Yang,
Lawrence W. Dobrucki ,
Isthier Chaudhury,
Qian Yin,
Catherine Yao,
Stéphane Lezmi,
William G. Helferich,
Timothy M. Fan,
Jianjun Cheng
This paper is available in a repository.
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Abstract
A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes with metastatic tumors.