In this paper a numerical analysis aimed at evaluating the thermal performance of vacuum insulation panels (VIPs) at the building scale is presented. This technology has seen considerable development over the past few years, gaining increasing penetration in the building insulation market. However, it is important to evaluate correctly the thermal bridging effect that occurs when the VIPs are coupled with joints at the building scale. To this purpose, the linear thermal transmittances of different VIP assemblies inserted in several wall configurations were assessed through a bidimensional numerical analysis. Moreover, to evaluate the influence of thermal bridges on the building energy need, quasi-steady-state simulations for a parametric building module were performed. A simple empirical model was finally built to estimate the linear thermal transmittance from basic input variables. The study demonstrates that thermal bridging effects that occur when VIPs are jointed are never negligible and they could have an important impact on the building heating energy need.