Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Reviews Molecular Cell Biology, 1(12), p. 14-20, 2010

DOI: 10.1038/nrm3029

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Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation

Journal article published in 2010 by David U. Mick ORCID, Thomas D. Fox, Peter Rehling
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.