Published in
Taylor and Francis Group, Communicative and Integrative Biology, 2(5), p. 217-219, 2012
DOI: 10.4161/cib.19145
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Dynamics of mitochondrial raft-like microdomains in cell life and death
,
Paola Matarrese,
Tina Garofalo ,
Antonella Tinari,
Lucrezia Gambardella,
Laura Ciarlo,
Valeria Manganelli,
Vincenzo Tasciotti,
Roberta Misasi,
Walter Malorni
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Abstract
On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, following CD95/Fas triggering, cellular prion protein (PrPC), which represents a paradigmatic component of lipid rafts, was redistributed to mitochondrial raft-like microdomains via endoplasmic reticulum (ER)-mitochondria associated membranes (MAM) and microtubular network.