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Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Journal article published in 2014 by Dagrun Engeset, Tonje Braaten, Birgit Teucher, Tilman Ku¨hn, Tilman Kuhn, Tilman Kühn, Hb B. Bueno de Mesquita, Max Leenders, Antonio Agudo, Manuela Mm Bergmann, Elisavet Valanou, Androniki Naska, Antonia Trichopoulou, Timothy J. Key, Francesca L. Crowe and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean fish, and fatty fish in a large prospective cohort including ten European countries. More than 500,000 men and women completed a dietary questionnaire in 1992???1999 and were followed up for mortality until the end of 2010. 32,587 persons were reported dead since enrolment. Hazard ratios and their 99 % confidence interval were estimated using Cox proportional hazard regression models. Fish consumption was examined using quintiles based on reported consumption, using moderate fish consumption (third quintile) as reference, and as continuous variables, using increments of 10 g/day. All analyses were adjusted for possible confounders. No association was seen for fish consumption and overall or cause-specific mortality for both the categorical and the continuous analyses, but there seemed to be a U-shaped trend (p