Dissemin is shutting down on January 1st, 2025

Published in

American Society for Microbiology, Journal of Virology, 4(77), p. 2762-2767, 2003

DOI: 10.1128/jvi.77.4.2762-2767.2003

Links

Tools

Export citation

Search in Google Scholar

Human Immunodeficiency Virus Type 1 Attachment, Coreceptor, and Fusion Inhibitors Are Active against both Direct andtransInfection of Primary Cells

Journal article published in 2003 by Thomas J. Ketas, Ines Frank, Per Johan Klasse, Brian M. Sullivan ORCID, Jason P. Gardner, Catherine Spenlehauer, Mirjana Nesin, William C. Olson, John P. Moore, Melissa Pope
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT Inhibitors of human immunodeficiency virus type 1 attachment (CD4-immunoglobulin G subclass 2), CCR5 usage (PRO 140), and fusion (T-20) were tested on diverse primary cell types that represent the major targets both for infection in vivo and for the inhibition of trans infection of target cells by virus bound to dendritic cells. Although minor cell-type-dependent differences in potency were observed, each inhibitor was active on each cell type and trans infection was similarly vulnerable to inhibition at each stage of the fusion cascade.