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Public Library of Science, PLoS ONE, 5(5), p. e10510, 2010

DOI: 10.1371/journal.pone.0010510

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Inhibition of Chemokine-Glycosaminoglycan Interactions in Donor Tissue Reduces Mouse Allograft Vasculopathy and Transplant Rejection

Journal article published in 2010 by Erbin Dai, Li-Ying Liu, Hao Wang, Dana McIvor, Yun Ming Sun, Colin Macaulay, Elaine King, Ganesh Munuswamy-Ramanujam, Mee Yong Bartee, Jennifer Williams, Jennifer Davids, Israel Charo, Grant McFadden, Jeffrey D. Esko, Alexandra R. Lucas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues. While chemokine-receptor binding has been extensively studied during allograft transplantation, effects of glycosaminoglycan (GAG) interactions with chemokines on transplant longevity are less well known. Here we examine the impact of interrupting chemokine-GAG interactions and chemokine-receptor interactions, both locally and systemically, on vascular disease in allografts.