Published in
Royal Society of Chemistry, RSC Advances, 69(6), p. 64544-64556, 2016
DOI: 10.1039/c6ra11041j
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Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity
Journal article published in 2016 by
Divyashree Ravishankar,
Kimberly A. Watson,
Francesca Greco,
Helen M. I. Osborn 
This paper is made freely available by the publisher.
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Abstract
Synthesis and antiproliferative evaluation of a library of 76 methoxy and hydroxy flavones, and their 4-thio analogues showed that the novel thioflavones15fand16fexhibit 7–46 fold greater anti-proliferative potency than the natural flavone chrysin (2d).