Wiley, Medical Physics, 9(40), p. 092503, 2013
DOI: 10.1118/1.4816944
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Purpose: Reconstruction of parametric images from dynamic single photon emission computed tomography (SPECT) data acquired with slow rotating cameras is a challenge because the estimation of the time–activity curves (TACs) may involve fitting data to an inconsistent underdetermined system of equations. This work presents a novel algorithm for the estimation of the blood input function and myocardial TAC with high accuracy and high efficiency directly from these projections.