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American Society for Microbiology, Infection and Immunity, 4(72), p. 2438-2441, 2004

DOI: 10.1128/iai.72.4.2438-2441.2004

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Yersinia pseudotuberculosis Anti-Inflammatory Components Reduce Trinitrobenzene Sulfonic Acid-Induced Colitis in the Mouse

Journal article published in 2004 by Michael Marceau ORCID, Laurent Dubuquoy, Christel Caucheteux-Rousseaux, Benoit Foligne ORCID, Pierre Desreumaux, Michel Simonet
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Rectal instillation of trinitrobenzene sulfonic acid (TNBS) induces acute colitis in the mouse. We tested the efficacy of Yersinia pseudotuberculosis anti-inflammatory components in preventing TNBS-triggered colitis. Animals were orally inoculated with virulence-attenuated Yersinia cells (a phoP mutant) prior to TNBS administration. Under these experimental conditions, colonic lesions and tumor necrosis factor alpha mRNA levels were significantly reduced.